Posts Tagged ‘toxicity’

New Colchicine Product and Dosing Regimen (October 2009)

Tuesday, October 6th, 2009

Video originally created by FDA -- posted by Lawsuit.com on October 6, 2009

FDA has approved the first single-ingredient oral colchicine product. The drug, called Colcrys, is approved to treat acute gout flares and familial Mediterranean fever. Oral colchicine has been used to treat gout in the past, but until now it had not been approved by FDA.

Colchicine has historically been given every hour for acute gout flares, either until the flare subsided or treatment had to be stopped because the patient developed gastrointestinal problems. But a dosing study conducted as part of the approval of Colcrys demonstrated that one initial dose and a single additional dose after one hour was just as effective and much less toxic. Healthcare professionals should use this lower recommended dosing regimen to treat acute gout flares.

Healthcare professionals should also be aware that colchicine interacts with other drugs, including P-glycoprotein and strong CYP3A4 inhibitors such as cyclosporine and clarithromycin. This can lead to serious or even fatal colchicine toxicity, particularly if a patient has renal or hepatic impairment. And so concomitant use of colchicine and P-glycoprotein or strong CYP3A4 inhibitors is contraindicated in these patients. For patients with normal renal and hepatic function, consider interrupting colchicine therapy or reducing the dose if the patient needs treatment with a P-glycoprotein or a strong CYP3A4 inhibitor.

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Help Patients Use Acetaminophen Safely (June 2009)

Wednesday, June 10th, 2009

Video originally created by FDA -- posted by Lawsuit.com on June 9th, 2009

Acetaminophen toxicity is a leading cause of acute liver failure, resulting in an estimated 400 deaths in the U.S. annually.  Many of these events are happening because patients are unknowingly taking too much of the drug.

Taking too much acetaminophen can easily occur because acetaminophen is widely found in a variety of both OTC and prescription drug products, including: up to 600 analgesics, antipyretics, cough/cold remedies and sleep aids.

Unintentional acetaminophen overdose may occur for several reasons, including:

  • people may not be aware that they are in danger of liver damage if they exceed the maximum recommended dose
  • alcohol exacerbates the risk of liver damage in acetaminophen users.
  • people may not realize how much acetaminophen they are consuming if they take more than one product containing acetaminophen.
  • peoplemay not look at over the counter drug labels to notice acetaminophenin the drug.

Pharmacists Findings Cause for Alarm

One study, published in the Journal of the American Pharmacists Association in 2007, surveyed 104 adult patients presenting to an internal medicine clinic. The findings were remarkable, including:

  • 79% reported using a product that contained acetaminophen within the previous six months, but only 43% could identify problems that could arise from high doses of acetaminophen. 71% of patients recognized that Tylenol contains acetaminophen.
  • less than 15% knew that Vicodin (hydrocodone/ acetaminophen), Darvocet (propoxyphene napsylate/) and Percocet (oxycodone/acetaminophen) contain acetaminophen.

Children are also at risk of acetaminophen overdose if they are given the adult formulation or the wrong pediatric formulation, if the dose is not calculated correctly for the child’s weight, or if the wrong dosing device is used.

FDA is encouraging health care providers to educate patients and caregivers about how to use pain medicines safely in the following ways.

  • Instruct about the correct dosing frequency for products that contain acetaminophen,
  • Be certain it is understood that having three or more alcoholic drinks per day can raise the risk of acetaminophen toxicity.
  • Warn  about taking multiple products containing the same active ingredient.
  • Instruct parents on the correct weight-based dose for their child and remind them to use the proper measuring device for liquid formulations.

Acetaminophen is a safe and effective analgesic and antipyretic when it is used properly. But careless or uninformed use can lead to serious liver damage and death. Healthcare providers can play an important role in protecting their patients from acetaminophen toxicity.

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Chinese Dry Wall, Respiratory Problems & Home Electrical Breakdowns

Wednesday, April 29th, 2009

Alert: Bodily Infections and Home Electrical Breakdowns?

Chinese Dry Wall

Chinese Dry Wall lawsuits are expected to surface. However, it is just as difficult to know who to sue as it is to receive treatment and repair homes damaged by Chinese Dry Wall.

Thousands of homes in the U.S. built over recent years contain Chinese Dry Wall. Many consumers may not realize that their home was built with Chinese Dry Wall. Yet, the people in homes that contain Chinese Dry Wall may be afflicted with debilitating respiratory infections, sinus infections, rashes, hair loss, hospitalization and irreparable harm to their homes because of Chinese Dry Wall.  The journey of one family in Florida signifies the need for all homeowners to check for Chinese Dry Wall and the right to a Chinese Dry Wall lawsuit.

Chinese Dry Wall Case in Point

“The Chinese Drywall in my new home is not covered by my insurer and my builder is bankrupt. The estimate is that it will cost a third of the home purchase price to fix it.  Since my whole family had been sick and there is electrical and a/c corrosion in the home, I had no choice but to leave our new home. It has been financially devastating,” explains John A. Willis, Attorney at Law and Shareholder at Kogan and DiSalvo, Boca Raton, Florida.

John purchased a new home two years ago. Within a few months after move in, all family members became ill. Notably, his son suffered from a severe sinus infection and was hospitalized. He was sent home from the hospital on IV antibiotics. His son continued to be ill and soon underwent sinus surgery to remove “rubber-like cement build up’, according to his physician. Simultaneously, John’s air conditioning system broke down. The HVAC repair man indicated that components in the air conditioning system had corroded. The HVAC repair man indicated that there was no reasonable explanation for the breakdown.  The family ultimately moved out of the home concerned for their safety when they learned that the home contained Chinese Dry Wall. In fact, approximately 45% of the other homeowners in John’s subdivision had Chinese Dry Wall. These people were forced to evacuate due to the risk of toxicity and unknown long term side effects. John filed an insurance claim, but the claim was rejected. He also attempted to investigate appropriate measures for remediation. Unlike mold damage, there is no protocol set for Chinese Dry Wall remediation. One company attempted to remove the dry wall, replaced piping with copper piping, and wrapped the piping in a saran wrap-like material. Very soon after all was replaced, corrosion occurred. It will take time before science understands how Chinese Dry Wall affects homes, groundwater, and the daily lives of those who have lived in homes containing Chinese Dry Wall.

As home building has boomed in the U.S. over the past five years, so has the need for home builders to turn to companies from abroad that produce dry wall. In fact, home builder income levels hit a national high in 2007 at close to $768 billion. States with the greatest contribution to the gross national product were Florida, Arizona, Nevada, Idaho, Colorado, Montana and states affected by Katrina, according to special study results published on www.housingeconomics.com

Chinese Dry Wall Safety Alert

The turn to Chinese Dry Wall was stimulated by this boom. Homes and commercial properties built or rebuilt between 2001 and 2008 may be more likely to be affected by toxicity should Chinese Dry Wall be present. At first glance, the negative effect for people exposed to the Chinese Dry Wall appears to be respiratory distress, nose bleeds, and headaches. Some of which are severe in nature. According to reports, the negative impact on homes includes:

  • Rotten egg smelling odor
  • Failure of appliances, including HVAC systems and coils in air conditioners, stoves and refrigerators
  • Corroded electrical wiring

The question remains “If Chinese Dry Wall can affect home appliances, think of what it can do to people?” The devastation from Chinese Dry Wall is under-reported at this time. It is not fully known how the chemicals responsible for toxicity in Chinese Dry Wall will ultimately affect people. The effects of toxicity in Chinese Dry Wall are estimated to be a major expense to homeowners and create a significant risk to for the public.

The Environmental Protection Agency was notified of the issues surrounding Chinese Dry Wall in August of 2008. Data is now being compiled by numerous authorities to learn more about Chinese Dry Wall toxicity. A select number of personal injury attorneys are investing in research to better identify causation and the outcome for people affected by Chinese Dry Wall toxicity. People affected by Chinese Dry Wall may contact Http://HomeownersConsumerCenter.com for more information.

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