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Warning on Exjade and Liver Failure

Posted on April 29, 2008

Novartis is warning healthcare professionals that hepatic failure can occur in patients treated with Exjade(deferasirox). Exjade is used to treat tranfusional hemosiderosis, the chronic iron overload that can result from multiple blood transfusions.

Cases of liver failure, some of them fatal, have been reported in patients treated with Exjade. Most of these cases occurred in patients over 55 years old who had significant comorbidities, including liver cirrhosis and multi-organ failure.

Because of this, liver function should be monitored monthly, and if there is unexplained, persistent, or progressive increase in serum transaminase levels, Exjade treatment should be modified or interrupted.

Additional Information:

FDA MedWatch Safety Alert. Exjade (deferasirox) Tablets For Oral Suspension. December 13, 2007.
http://www.fda.gov/medwatch/safety/2007/safety07.htm#Exjade

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